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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Structure. 2022 Nov 2;30(12):1615–1625.e4. doi: 10.1016/j.str.2022.10.003

Figure 4. Mutations in CDK11 cause resistance to OTS964.

Figure 4.

(A) Western-blot demonstrating level of CDK11 expression in A375 cell lines stably expressing either CDK11 wild-type or mutants.

(B) Representative clonogenic assay of A375 cells stably expressing either CDK11 wild-type or the indicated CDK11 mutants in 6-well tissue culture plates (diameter 35 mm) after 12 days of treatment with 100 nM OTS964. Representative images of three independent replicates.

(C) Relative confluence of A375 cell lines stably expressing either CDK11 wild-type or the indicated CDK11 mutants after 12 days of treatment with 100 nM OTS964. Quantification of three independent biological replicates, mean ± standard error (SEM).