Corrigendum: The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside

In the published article, there was an error in Figures 2, 3 as published. The panels in Figure 2 are labelled A, B, C, D, E, E, and F and in Figure 3 A, B, C, D, D, E, and F, while both were initially intended as A, B, C, D, E, F, G.

FIGURE 2.

The effect of mitochondrial modifiers and GlcNAc supplementation on the lifespan and onset of neurological phenotypes of Ercc1 ^Δ/− mice. (A–D), Comparison between Ercc1 ^Δ/− control mice and animals supplemented with sodium nitrite, DCA, or GlcNAc on water intake (A), food intake (B), bodyweight over time (C) and body weight as area under the curve (AUC) of measurements between 6–16 weeks (D). (E–G), Onset of neurological abnormalities; tremors (E) and imbalance (F), and survival (G) of the same animals. Indicated values are Mean (±SD). Significant p values of the Dunnet’s multiple comparison test (A,E,F) are indicated.

FIGURE 3.

The effect of nicotinamide ribosome supplementation on the lifespan and onset of neurological phenotypes of Ercc1 ^Δ/− mice. (A–C), Values of water intake (A), food intake (B) body weight changes over time (C) and body weight as area under the curve (AUC) (D) in control animals and animals receiving supplementation of two NAD⁺ precursors; NA and NR. (E–F), Onset of neurological abnormalities; tremors (E) and imbalance (F) with age of Ercc1 ^Δ/− control mice and mice receiving NR or NA. (G). Survival curve showing lifespan of the three groups. Indicated values are Mean (±SD). Significant p values of the Dunnet’s multiple comparison test (A) and log-rank survival test (F,G) are indicated.

The corrected Figures 2, 3 appear below.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.