aDepartment of Paediatric Haematology and Oncology, University Hospital Bonn, Bonn, Germany
bDepartment of Medical Biometry, Informatics, and Epidemiology, University Hospital Bonn, Bonn, Germany
cIWK Health Centre, Dalhousie University, Halifax, NS, Canada
dZentrum fu¨r Kinder-, Jugend- und Frauenmedizin, Pa¨diatrie, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany
eDepartment of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent, Belgium
fDepartment of Clinical Sciences, Department of Paediatrics, Lund University, Skane University Hospital, Lund, Sweden
gDana-Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA
hWomen’s Services Clinical Board, University Hospital of Wales, Cardiff, UK
iStatistics and Data Center, Children’s Oncology Group, Monrovia, CA, USA
jFive Prime Therapeutics, South San Francisco, CA, USA
kDivision of Oncology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
lNorwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
mMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK
nDepartment of Paediatric Haematology and Oncology, Ghent University Hospital, Ghent, Belgium
oDepartment of Oncology, University College Hospital, London, UK
pWest German Proton Therapy Center Essen, Essen, Germany
∗Corresponding author: axel.budde@ukbonn.de
1These authors contributed equally to this work.