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Nrf2 deficiency promotes CLP-induced M1 macrophage polarization and apoptosis in lung tissues. n = 6 mice per group. (A,B) Immunofluorescence staining of iNOS and F4/80 in the lung tissues of each group. (C,D) TUNEL staining presented apoptotic cells in the lung tissues of WT and Nrf2−/− mice before or after CLP treatment. (E,F) Western blot analyses of apoptosis-associated proteins such as Bcl-2, Bax, and Cleaved—caspase3 in the lung tissues of each group. ** p < 0.01, *** p < 0.001.
