Persistent Parental RNAi in the Beetle Tribolium castaneum Involves Maternal Transmission of Long Double‐Stranded RNA (Advanced Genetics 3/03)

Abstract

dsRNA Uptake

In article 2100064 by Kristen A. Panfilio and co‐workers, the cuticle exoskeleton of flour beetle larvae reveals normal anatomy (above: head‐to‐tail in blue‐to‐red) and long‐term parental RNAi knockdown (below), here showing a mirror‐image duplication of the abdomen (red termini to yellow center). Strong knockdown can persist for months despite transmission of full‐length double‐stranded RNA (dsRNA) from the mother into the egg, depleting maternal dsRNA levels.