80. SARS-CoV-2 infection is associated with decreased reported physical fitness in a US military longitudinal cohort

Stephanie A Richard; Ann Scher; Jennifer Rusiecki; Celia Byrne; Catherine M Berjohn; Anthony C Fries; Tahaniyat Lalani; Alfred G Smith; Rupal Mody; Anuradha Ganesan; Nikhil Huprikar; Rhonda E Colombo; Christopher Colombo; David A Lindholm; Katrin Mende; Milissa Jones; Derek Larson; Evan C Ewers; Samantha Bazan; Charlotte Lanteri; David Saunders; Ryan C Maves; Jeffrey Livezey; Margaret Sanchez Edwards; Julia S Rozman; David R Tribble; Brian Agan; Simon Pollett; Mark P Simons; Timothy Burgess

doi:10.1093/ofid/ofac492.005

. 2022 Dec 15;9(Suppl 2):ofac492.005. doi: 10.1093/ofid/ofac492.005

80. SARS-CoV-2 infection is associated with decreased reported physical fitness in a US military longitudinal cohort

Stephanie A Richard ¹, Ann Scher ², Jennifer Rusiecki ³, Celia Byrne ⁴, Catherine M Berjohn ⁵, Anthony C Fries ⁶, Tahaniyat Lalani ⁷, Alfred G Smith ⁸, Rupal Mody ⁹, Anuradha Ganesan ¹⁰, Nikhil Huprikar ¹¹, Rhonda E Colombo ¹², Christopher Colombo ¹³, David A Lindholm ¹⁴, Katrin Mende ¹⁵, Milissa Jones ¹⁶, Derek Larson ¹⁷, Evan C Ewers ¹⁸, Samantha Bazan ¹⁹, Charlotte Lanteri ²⁰, David Saunders ²¹, Ryan C Maves ²², Jeffrey Livezey ²³, Margaret Sanchez Edwards ²⁴, Julia S Rozman ²⁵, David R Tribble ²⁶, Brian Agan ²⁷, Simon Pollett ²⁸, Mark P Simons ²⁹, Timothy Burgess ^30,¹

¹ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, MD

² Uniformed Services University of the Health Sciences, Bethesda, Maryland

³ Uniformed Services University of the Health Sciences, Bethesda, Maryland

⁴ Uniformed Services University of the Health Sciences, Bethesda, Maryland

⁵ Naval Medical Center San Diego Division of Infectious Diseases, Infectious Disease Clinical Research Program, San Diego, CA

⁶ U.S. Air Force School of Aerospace Medicine, Dayton, Ohio

⁷ Naval Medical Center Portsmouth, Portsmouth, Virginia

⁸ Division of Infectious Diseases, Naval Medical Center, Portsmouth, Virginia, USA, Portsmouth, Virginia

⁹ William Beaumont Army Medical Center, El Paso, Texas

¹⁰ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Walter Reed National Military Medical Center, Bethesda, Maryland

¹¹ Walter Reed National Military Medical Center, Bethesda, Maryland

¹² Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Madigan Army Medical Center Division of Infectious Diseases, Tacoma, Washington

¹³ Madigan Army Medical Center, Tacoma, Washington

¹⁴ Brooke Army Medical Center, Bethesda, Maryland

¹⁵ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, MD

¹⁶ Tripler Army Medical Center, Honolulu, Hawaii

¹⁷ Naval Medical Center San Diego, san diego, California

¹⁸ Fort Belvoir Community Hospital, Fort Belvoir, Virginia

¹⁹ Carl R. Darnall Army Medical Center, Fort Hood, Texas

²⁰ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland

²¹ Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, Maryland

²² Wake Forest University School of Medicine, Winston-Salem, North Carolina

²³ Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, Maryland

²⁴ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health SciencesHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland

²⁵ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, MD

²⁶ Uniformed Services University of the Health Sciences, Bethesda, Maryland

²⁷ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, MD

²⁸ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, MD

²⁹ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, MD

³⁰ Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA, Bethesda, MD

Epidemiology, Immunology, and Clinical Characteristics of Emerging Infectious Diseases with Pandemic Potential (EPICC)

Session: 30. COVID-19: Post-Acute Sequelae

Thursday, October 20, 2022: 11:30 AM

PMCID: PMC9751972

Abstract

Background

COVID-19 may have deleterious effects on the fitness of active duty US military service members. We seek to understand the long-term functional consequences of SARS-CoV-2 infection in this critical population, and in other military healthcare beneficiaries.

Methods

The Epidemiology, Immunology, and Clinical Characteristics of Emerging Infectious Diseases with Pandemic Potential (EPICC) study is a longitudinal cohort study to describe the outcomes of SARS-CoV-2 infection in US Military Health System beneficiaries. Subjects provided information about difficulties experienced with daily activities, exercise, and physical fitness performance via electronic surveys. Subjects completed surveys at enrollment and at 1, 3, 6, 9, and 12 months.

Results

5,910 subjects completed survey fitness questions, 3,244 (55%) of whom tested SARS-CoV-2 positive at least once during the period of observation. Over 75% of subjects were young adults and over half were male (Table 1). 1,093 (34.3%) of SARS-CoV-2-positive subjects reported new or increased difficulty exercising compared to 393 (14.8%) SARS-CoV-2 negative subjects (p < 0.01) (Table 2). The most commonly reported symptoms related to problems with exercise and activities were dyspnea and fatigue. Among the active-duty members who answered the question about their service-mandated physical fitness test scores, 43.2% of SARS-CoV-2-positive participants reported that their scores had worsened in the study period, compared with 24.3% of SARS-CoV-2 negative participants. Among SARS-CoV-2-positive subjects, reports of difficulty exercising and performing daily activities were highest within one month of the first positive test, decreasing in prevalence among the cohort only slightly to 24% and 18%, respectively, at 12 months (Figure 1).

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Conclusion

A substantial proportion of military service-members in this cohort have reported impairment of their service-mandated physical fitness scores after COVID-19; this proportion is significantly higher than those who are SARS-CoV-2 negative and persists to 12 months in many; similar complaints were reported among non-active duty. Further objective evaluation of post-COVID fitness impairment in this population is warranted.

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Disclosures

Ryan C. Maves, MD, AiCuris: Grant/Research Support|Sound Pharmaceuticals: Grant/Research Support|Trauma Insights, LLC: Advisor/Consultant Julia S. Rozman, n/a, Astra Zeneca: The HJF, in support of the USU IDCRP, was funded to conduct or augment unrelated Phase III Mab and vaccine trials as part of US Govt. COVID19 response David R. Tribble, DrPH, AstraZeneca: The HJF, in support of the USU IDCRP, was funded to conduct or augment unrelated Phase III Mab and vaccine trials as part of US Govt. COVID19 response Simon Pollett, MBBS, Astra Zeneca: The HJF, in support of the USU IDCRP, was funded to conduct or augment unrelated Phase III Mab and vaccine trials as part of US Govt. COVID19 response Mark P. Simons, PhD, AstraZeneca: The HJF, in support of the USU IDCRP, was funded to conduct or augment unrelated Phase III Mab and vaccine trials as part of US Govt. COVID19 response Timothy Burgess, MD, MPH, AstraZeneca: The HJF, in support of the USU IDCRP, was funded to conduct or augment unrelated Phase III Mab and vaccine trials as part of US Govt. COVID19 response.

PERMALINK

80. SARS-CoV-2 infection is associated with decreased reported physical fitness in a US military longitudinal cohort

Stephanie A Richard, PhD, MHS

Ann Scher, PhD

Jennifer Rusiecki, PhD

Celia Byrne, PhD

Catherine M Berjohn, MD, MPH

Anthony C Fries, PhD

Tahaniyat Lalani, MBBS, MHS

Alfred G Smith, D.O.

Rupal Mody, MD

Anuradha Ganesan, MD

Nikhil Huprikar, MD

Rhonda E Colombo, MD, MHS

Christopher Colombo, MD

David A Lindholm, MD

Katrin Mende, PhD

Milissa Jones, MD, MPH, FAAP

Derek Larson, DO

Evan C Ewers, MD

Samantha Bazan, DNP

Charlotte Lanteri, PhD

David Saunders, MD

Ryan C Maves, MD

Jeffrey Livezey, MD

Margaret Sanchez Edwards, MS

Julia S Rozman, n/a

David R Tribble, DrPH

Brian Agan, MD

Simon Pollett, MBBS

Mark P Simons, PhD

Timothy Burgess, MD, MPH

Abstract

Background

Methods

Results

Conclusion

Disclosures

ACTIONS

PERMALINK

RESOURCES

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