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. 2022 Dec 6;99(23):e2535–e2547. doi: 10.1212/WNL.0000000000201186

Figure 1. Methodologic Sequence for Identifying Data-Driven WMH Spatial Patterns.

Figure 1

(A) Image analysis pipeline includes standard preprocessing of both FLAIR and corresponding T1-weighted MRI data, (B) image-level harmonization to account for batch effects, (C) automated WMH segmentation using a custom deep learning network (U-Net), (D) alignment to standard brain template to ensure cohort-level spatial correspondence of the WMH probability maps, and (E) voxel-based spectral clustering of aligned WMH probability maps.