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. 2022 Dec 16;37(1):57–71. doi: 10.1007/s40259-022-00572-4
NKT cells can directly mediate lysis of infected and cancer cells, as well as induce other effector cells through their expeditious release of cytokines.
Adoptive transfer of NKT cells into cancer patients holds promise as NKT cells can target these cells and mediate protection.
Current immunotherapeutic strategies using chimeric antigen receptors, bispecific T cell engagers, and tumor vaccines are being developed to harness the potential of NKT cells.