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. 2022;2453:297–316. doi: 10.1007/978-1-0716-2115-8_17

Adaptive Immune Receptor Repertoire (AIRR) Community Guide to Repertoire Analysis.

Susanna Marquez, Lmar Babrak, Victor Greiff, Kenneth B Hoehn, William D Lees, Eline T Luning Prak, Enkelejda Miho, Aaron M Rosenfeld, Chaim A Schramm, Ulrik Stervbo; AIRR Community
PMCID: PMC9761518  PMID: 35622333

Abstract

Adaptive immune receptor repertoires (AIRRs) are rich with information that can be mined for insights into the workings of the immune system. Gene usage, CDR3 properties, clonal lineage structure, and sequence diversity are all capable of revealing the dynamic immune response to perturbation by disease, vaccination, or other interventions. Here we focus on a conceptual introduction to the many aspects of repertoire analysis and orient the reader toward the uses and advantages of each. Along the way, we note some of the many software tools that have been developed for these investigations and link the ideas discussed to chapters on methods provided elsewhere in this volume.

Full text of this article can be found in Bookshelf.

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