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. 2022 Dec 19;9(35):2270226. doi: 10.1002/advs.202270226

Macrophage Reprogramming with Anti‐miR223‐Loaded Artificial Protocells Enhances In Vivo Cancer Therapeutic Potential (Adv. Sci. 35/2022)

Paco López‐Cuevas, Can Xu, Charlotte E Severn, Tiah C L Oates, Stephen J Cross, Ashley M Toye, Stephen Mann, Paul Martin
PMCID: PMC9762276

Abstract

Macrophage Reprogramming

In article number 2202717, Stephen Mann, Paul Martin, and co‐workers used a zebrafish model of melanoma, which develops human‐like tumors mainly in the tail, to test a novel cancer immunotherapy approach based on the intravenous or direct injection of miniature artificial protocells that can circulate in blood and deliver reprogramming cargoes to immune cells to enhance their anti‐cancer potential.

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