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. 2022 Dec 19;71(11):2460–2466. doi: 10.1007/s11172-022-3674-0

4-Hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]triazines: synthesis, antiviral activity, and electrochemical characteristics

R A Drokin 1,✉, E A Fesenko 1, P N Mozharovskaia 1, M V Medvedeva 1, T S Svalova 1, A N Kozitsina 1, Ya L Esaulkova 3, A S Volobueva 3, V V Zarubaev 3, V L Rusinov 1,2
PMCID: PMC9762649  PMID: 36569657

Abstract

A new method for preparation of 4-hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]-triazines using 1-nitro-2-morpholinoethylene and 3-diazo-1,2,4-triazoles is proposed. Antiviral activity against the Coxsackie B3 virus and electrochemical transformations of the prepared compounds are studied.

Key words: 3-nitroazolo[5,1-c][1,2,4]triazines; azolotriazines; triazines; antiviral activity; Coxsackie B3 virus; voltammetry; electrochemical properties

Footnotes

Based on the materials of the V Russian Conference on Medicinal Chemistry with international participation “MedChem-Russia 2021” (May 16–19, 2022, Volgograd, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2460–2466, November, 2022.

This work was performed under financial support of the Russian Science Foundation (Project No. 20-13-00142).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Contributor Information

R. A. Drokin, Email: drokinroman@gmail.com

V. V. Zarubaev, Email: zarubaev@gmail.com

V. L. Rusinov, Email: rusinov@htf.ustu.ru

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