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Light-stimulated OptoLRP6 activation rescues BEC disruption after Aβ oligomer treatment. (A) Schematic diagram of experiment design. (B) Axin2 mRNA expression, (C) immunostaining and quantification of Cldn5, Zo-1 and Glut1 (scale bar = 20 µm), (D) protein levels of Cldn5 and Glut1, (E) Cldn5 mRNA expression and (F) in vitro trans-well permeability assay in BECs. Data are presented as mean ± SEM, n = 3, *P < 0.05, **P < 0.01.
