Appendix 1—table 5. Associations of phenotypes and polygenic scores within parental pairs^*.

Phenotypes: regression of father’s BMI, depressive symptoms, and ADHD symptoms on mother’s phenotypes
	Father’s: BMI	Father’s: Depressive symptoms	Father’s: ADHD symptoms
	Beta (95% CI), p	Beta (95% CI), p	Beta (95% CI), p
Mother’s: BMI	0.23 (0.22,0.25) p<0.001	0.01 (-0.00,0.02) p=0.09	0.03 (0.02,0.05) p<0.001
Mother’s: Depressive symptoms	0.00 (-0.01,0.01), p=0.85	0.18 (0.16,0.20) p<0.001	0.10 (0.09,0.12), P<0.001
Mother’s: ADHD symptoms	0.01 (-0.02,0.01) p=0.32	0.05 (0.05,0.06) p<0.001	0.11 (0.09,0.13) p<0.001
Polygenic scores: regression of father’s PGS for BMI, depression, and ADHD: regression of father’s PGS on mother’s PGS
	Father’s: Adult BMI PGS	Father’s: Childhood body size PGS	Father’s: Depression PGS	Father’s: ADHD PGS
	Beta (95% CI), p	Beta (95% CI), p	Beta (95% CI), p	Beta (95% CI)
Mother’s: Adult BMI PGS	0.01 (0.00,0.02), p=0.02	0.01 (0.00,0.02), p=0.008	–0.00 (-0.01,0.01), p=0.62	–0.00 (-0.01,0.01), p=0.49
Mother’s: Childhood body size PGS	0.01 (-0.00,0.02), p=0.10	0.01 (-0.00,0.02), p=0.15	0.00 (-0.00,0.01), p=0.33	0.01 (0.00,0.02), p=0.03
Mother’s: Depression PGS	–0.01 (−0.02–0.00), p=0.11	–0.00 (-0.01,0.01), p=0.76	–0.00 (-0.01,0.01), p=0.44	–0.00 (-0.01,0.01), p=0.47
Mother’s: ADHD PGS	–0.00 (-0.01,0.01), p=0.58	0.01 (-0.00,0.02), p=0.24	–0.00 (-0.01,0.01), p=0.42	–0.00 (-0.01,0.01), p=0.93

^*All models adjusted for the first 20 principal components of ancestry, genotyping centre and genotyping chip of the mother and father.