Figure 4.

L1 ceRNA activity potentially relies on autonomous L1 transcription and Ago2 levels. (A). Top-10 deregulated TE families in ATRX model. Both in iPSC cells and in neurons, L1 family is the most upregulated TE family. (B). Analysis to detect autonomous transcription of L1 elements in ATRX model. Upon the KO of ATRX, the upregulation of L1 elements seems not to derive from an autonomous transcription of elements in neurons. (C). Analysis of miRNA target sites sharing between active L1s and the 3′UTRs of protein-coding genes in ATRX model. Downregulated genes show a higher number of miRNA target sites in common with overexpressed L1s. (D). Comparative analysis of Ago2 expression levels in all analyzed datasets.