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. 2022 Dec 22;5:1403. doi: 10.1038/s42003-022-04377-7

Author Correction: Biosynthesis of cannabinoid precursor olivetolic acid in genetically engineered Yarrowia lipolytica

Jingbo Ma 1,2, Yang Gu 1,3, Peng Xu 1,4,
PMCID: PMC9780227  PMID: 36550204

Correction to: Communications Biology 10.1038/s42003-022-04202-1, published online 12 November 2022.

The original version of this Article had several incorrect references in the following paragraphs of the Results and Discussion section:

Last sentence of subheading “Biosynthesis of olivetolic acid in engineered Y. lipolytica”:

“The resulting strain YL101 only produced 0.11 mg/L OLA after 96 h cultivation (Fig. 2b), which is comparable to the initial OLA production in S. cerevisiae19.”

The correct version of this paragraph should appear as:

“The resulting strain YL101 only produced 0.11 mg/L OLA after 96 h cultivation (Fig. 2b), which is comparable to the initial OLA production in S. cerevisiae17.”

Second paragraph of subheading “Screening enzymes to improve pool size of hexanoyl-CoA”:

“ [..] We also removed the C-terminal peroxisome targeting sequence 1 (PTS1) and overexpressed the codon-optimized CsAAE3 in Y. lipolytica20,21,22. […] The LvaE gene encoding the short-chain acyl-CoA synthetase of Pseudomonas putida KT2440 (PpLvaE, PP_2795 with uniport ID Q88J54), which is reported to active with C4-C6 carboxylic acids, was also selected19. […]. The overexpression of CsAAE1 in S. cerevisiae only showed a twofold increase in OLA titer19. […]”

The correct version of this paragraph should appear as:

“ [..] We also removed the C-terminal peroxisome targeting sequence 1 (PTS1) and overexpressed the codon-optimized CsAAE3 in Y. lipolytica19-21. […] The LvaE gene encoding the short-chain acyl-CoA synthetase of Pseudomonas putida KT2440 (PpLvaE, PP_2795 with uniport ID Q88J54), which is reported to active with C4-C6 carboxylic acids, was also selected22. […]. The overexpression of CsAAE1 in S. cerevisiae only showed a twofold increase in OLA titer17. […]”

These have now been corrected in the PDF and HTML versions of the Article.


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