Table 1.
Characteristics of the patients.
| Tolerance n = 14 |
Intolerance n = 10 |
p | |
|---|---|---|---|
| Age median (IQR) | 62 (50, 68) | 61 (52, 65) | 0.75 |
| Male n (%) | 7 (50.00%) | 6 (60.00%) | 0.62 |
| APACHE II median (IOR) | 12 (10, 21) | 15 (12, 23) | 0.26 |
| SOFA median (IQR) | 6.5 (9, 4) | 9 (6, 14) | 0.09 |
| Weight Kg | 48 (45, 68) | 50 (40, 82) | 0.72 |
| mNutric | 5 (3, 6) | 5 (4, 6) | 0.73 |
| Estimated energy intake (Kcal/day) Median (IOR) |
1000 (800, 1500) |
1000 (800, 1500) |
0.74 |
| EN energy intake on day 3 (Kcal/day) Median (IQR) |
950 (700, 1000) |
500 (300, 600) |
0.02 |
| 28-day survival n (%) | 9 (64.28%) | 5 (50.00%) | |
| Comorbidity | |||
| Diabetes | 4 (28.57%) | 4 (40.00%) | 0.55 |
| Hypertension | 6 (42.86%) | 5 (50.00%) | 0.72 |
| COPD | 7 (50.00%) | 6 (60.00%) | 0.62 |
| Coronary vascular disease | 5 (35.71%) | 6 (60.00%) | 0.23 |
| Days before ICU | 5 (3, 14) | 4 (2, 10) | 0.21 |
| Infection site n (%) | |||
| Respiratory | 11 (78.57%) | 5 (50.00%) | 0.14 |
| Blood | 2 (14.29%) | 1 (10.00%) | 0.75 |
| Urine | 1 (7.14%) | 0 (0%) | 0.38 |
| Central nervous system | 1 (7.14%) | 0 (0%) | 0.38 |
| Maximal AGI from day 1 to day 3 n (%) | 6 (42.86%) | 3 (30.00%) | 0.52 # |
| Grade I | 2 (14.29%) | 1 (10.00%) | |
| Grade II | 4 (28.57%) | 2 (20.00%) | |
| Grade III | 8 (57.14%) | 6 (60.00%) | |
| Grade IV | 0 (0.00%) | 1 (10.00%) | |
| GI symptoms from day 1 to day 3 n (%) | |||
| Nausea/vomiting | 5 (35.71%) | 6 (60.00%) | 0.23 |
| Diarrhea | 3 (21.43%) | 4 (40.00%) | 0.32 |
| Abdominal distension | 5 (35.71%) | 5 (50.00%) | 0.48 |
| Organ support | |||
| Mechanical ventilation | 6 (42.86%) | 6 (60.00%) | 0.40 |
| Vasopressor | 10 (71.43%) | 8 (80.00%) | 0.63 |
| Antibiotic regimen n (%) | |||
| Carbapenems | 10 (71.42%) | 6 (60.00%) | 0.56 |
| The 3rd/4th generation of cephalosporin | 2 (14.29%) | 3 (30.00%) | 0.35 |
| β-lactams/β-lactamase inhibitors | 2 (14.29%) | 1 (10.00%) | 0.75 |
| Vancomycin | 4 (28.57%) | 3 (30.00%) | 0.97 |
| Combination of any two above | 4 (28.57%) | 3 (30.00%) | 0.97 |
| Pathogen n (%) | |||
| Staphylococcus aureus | 1 (7.14%) | 1 (10.00%) | 0.80 |
| Candida | 3 (21.43%) | 2 (20.00%) | 0.93 |
| Enterobacteria | 1 (7.14%) | 3 (30.00%) | 0.19 |
| Acinetobacter | 5 (35.72%) | 5 (50.00%) | 0.48 |
| Undefined | 2 (14.29%) | 2 (20.00%) | 0.71 |
AGI, acute gastrointestinal injury; IQR, interquartile range; #, Mantel–Haenszel test.