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DDI ratio for Cmax and AUClast calculated for the administration of MDZ together with POS.
| POS | MDZ 0.4 mg i.v. SD |
MDZ 2.0 mg Oral SD |
||
|---|---|---|---|---|
| DDI Ratio | Cmax | AUClast | Cmax | AUClast |
| 200 mg oral SUS | 1.42 a 1.30 b |
3.38 a 4.42 b |
2.74 a 2.20 b |
5.54 a 4.99 b |
| 400 mg oral SUS | 1.41 a 1.68 b |
4.43 a 6.23 b |
3.02 a 2.33 b |
6.95 a 5.26 b |
a DDI ratio for Cmax and AUClast calculated with MDZ and POS model. b Values taken from the literature (in vivo) [44].
