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. 2022 Dec 18;14(12):2840. doi: 10.3390/pharmaceutics14122840
A heat transfer surface area, m2
A m heat transfer surface area of the mill chamber, m2
c bead loading or fractional volumetric concentration of the beads, –
C p specific heat capacity, J/g °C
EBM enthalpy balance model
D b bead size, µm
LPM lumped-parameter model
m mass in the mill chamber, g
ML machine learning
PL power law
P power consumption, J/min
heat generation rate during milling, retrieved from EBM study, J/min
Q gen apparent heat generation during milling, J/min
RMSE root-mean-squared error, °C
T temperature at the mill outlet, °C
T ch chiller temperature, °C
T rise temperature rise at 6 min of milling, °C
T 0 initial temperature at the mill outlet, °C
t milling time, min
U overall heat transfer coefficient, W/m2 °C
UA apparent overall heat transfer coefficient times surface area, J/min °C
UA m apparent overall heat transfer coefficient times surface area in the mill chamber, J/min °C
ξ fraction of mechanical power converted into heat, –
ω stirrer (rotational) speed, rpm