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I too was interested in the extraordinary outcome of this single-centre trial,1,2 and it has unquestionably influenced my practice since its publication. Thankfully, and ethics notwithstanding, this same question HAS been studied again in a UK population.2
For better or worse this large trial did not support the outcomes of the earlier study, so it is best to advise patients to take their tablets at a time most convenient for them.
REFERENCES
- 1.Bal G, Kim CS. Should we be advising patients to take their antihypertensives at night? [Letter] Br J Gen Pract. 2022. DOI: . [DOI] [PMC free article] [PubMed]
- 2.Hermida RC, Crespo JJ, Domínguez-Sardiña M, et al. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J. 2020;41(48):4565–4576. doi: 10.1093/eurheartj/ehz754. [DOI] [PubMed] [Google Scholar]
- 3.Mackenzie IS, Rogers A, Poulter NR, et al. Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial. Lancet. 2022;400(10361):1417–1425. doi: 10.1016/S0140-6736(22)01786-X. [DOI] [PMC free article] [PubMed] [Google Scholar]