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. 2023 Jan 1;13(1):77–94. doi: 10.7150/thno.77404

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Expression of miR-182 is lower in primary AML blasts than normal controls (NCs). (A) The expressions of miR-182 were measured in bone marrow (BM) mononuclear cells from untreated AML patients and NCs by qRT-PCR. (B and C) The expressions of miR-182 were analyzed in untreated AML patients bearing various chromosomal translocations in comparison to NCs. (D and E) The expressions of miR-182 were analyzed in untreated AML patients according to FAB subtypes (M1-M5) compared with NCs. (F) The expressions of miR-182 were measured in CD34⁺ and CD34^- BM cells isolated from seven AML patients. (G and H) Overall survival time (OS, G) and disease free-survival time (DFS, H) were analyzed in AML patients with higher (above the median miR-182 expression) levels of miR-182 in comparison to those with lower (below the median miR-182 expression) levels of miR-182. (I and J) The percentages of leukemic blasts in BM (I) and PB (J) were analyzed in AML patients with low expressions of miR-182 (below median) and high expressions of miR-182 (above median). *P < 0.05; **P < 0.01; ***P < 0.001.