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. 2023 Jan 1;13(1):20–39. doi: 10.7150/thno.76894

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Mannose-modified cancer cell membrane-cloaked PLGA NPs loaded with R837 (NP-R@M-M) acted as an effective anticancer vaccine. (A) Proposed mechanism of action and (B) preparation procedure of NP-R@M-M. (C) Dendritic cell (DC) maturation after treatment with the indicated NP formulations. The cells were stained with CD11c antibodies as DC markers and CD80 and CD86 antibodies to label mature DCs. (D) The percentages of CD107a⁺ T cells determined by flow cytometry after intradermal injection with the different vaccine formulations. (E) IFN-γ concentration in sera drawn from the treated mice as determined by ELISA. Adapted with permission from ⁹², copyright 2018, American Chemical Society.