Dear Editor, we would like to share ideas on the publication “Correlation of adverse effects and antibody reponses following homologous and heterologous COVID19 prime-boost vaccinations.1 Cheng et al. looked at whether adverse reactions to previous COVID-19 vaccines may predict humoral responses with any degree of accuracy.1 According to Cheng et al., some reactogenic symptoms, such as pain, swelling, erythema, fever, myalgia, and weariness at the injection site after vaccination, are strongly predictive of the strength of the anti-SARS-CoV-2 antibody response.1 We agree that the background vaccination might have effect of the immunogenicity and reactiogenicity of the booster.
It is frequently challenging to pinpoint the precise clinical link because there is little clinical information available on the health and immunological status of vaccination recipients prior to injection. Comorbidities do exist, however they are rarely taken into account in published research. Due to the limited information on the health and immunological status of vaccine recipients before injection, establishing the precise therapeutic link might occasionally be difficult. The patient's comorbidities may have contributed to the problem. One noteworthy example is the possibility of concomitant dengue infection, which could result in clinical issues.2 Due to the limited information on the health and immunological status of vaccine recipients before injection, establishing the precise therapeutic link might occasionally be difficult. The patient's comorbidities may have contributed to the problem. Due to the limited information on the health and immunological status of vaccine recipients before injection, establishing the precise therapeutic link might occasionally be difficult.
The patient's comorbidities may have contributed to the problem. Finding the precise clinical relationship can be difficult at times. Additionally, studies have shown that the genetic diversity of persons who inherit them affects immunological responses. According to a study,3 genetic factors influence how people's immune systems react to vaccinations. It is necessary to perform a test before reaching a decision. More research is necessary to rule out any additional exacerbating factors, such as co-morbidity or an underlying pathological condition. Furthermore, it is critical to consider any current or previous asymptomatic COVID-19 infections. Given the rarity of the situation, it might be a good idea to take it into account.4
Declaration of competing interest
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References
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