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PUFAs are primarily metabolized the CYPs, lipoxygenases (LOX), and cyclooxygenases (COX) with overlapping oxylipin biosynthesis capabilities. LA = linoleic acid (18:2); AA = arachidonic acid (20:4); ALA = α-linolenic acid (18:3); EPA = eicosapentaenoic acid (20:5); DHA = docosahexaenoic acid (22:6).
