Table 1.
Orthologous detoxification CYP subfamilies between human, rat, and mouse.
| CYP Subfamily | Human | Mouse | Rat |
|---|---|---|---|
| CYP1A | CYP1A1, 1A2 | Cyp1a1, 1a2 | Cyp1a1, 1a2 |
| CYP1B | CYP1B1 | Cyp1b1 | Cyp1b1 |
| CYP2A | CYP2A6, 2A7, 2A13 | Cyp2a4, 2a5, 2a12, 2a22 | Cyp2a1, 2a2, 2a3 |
| CYP2B | CYP2B6 | Cyp2b9, 2b10, 2b13, 2b19, 2b23 | Cyp2b1, 2b2, 2b3, 2b12, 2b15, 2b21 |
| CYP2C | CYP2C8, 2C9, 2C18, 2C19 | Cyp2c29, 2c37, 2c38, 2c39, 2c40, 2c44, 2c50, 2c54, 2c55, 2c65, 2c66, 2c67, 2c68, 2c69, 2c70 | Cyp2c6, 2c7, 2c11, 2c12, 2c13, 2c22, 2c23, 2c24, 2c78, 2c80 |
| CYP2D | CYP2D6 | Cyp2d9, 2d10, 2d11, 2d12, 2d13, 2d22, 2d26, 2d34, 2d40 | Cyp2d1, 2d2, 2d3, 2d4, 2d5 |
| CYP2E | CYP2E1 | Cyp2e1 | Cyp2e1 |
| CYP2J | CYP2J2 | Cyp2j5, 2j6, 2j7, 2j8, 2j9, 2j11, 2j12, 2j13 | Cyp2j3, 2j4, 2j10, 2j13, 2j16 |
| CYP2S | CYP2S1 | Cyp2s1 | Cyp2s1 |
| CYP2U | CYP2U1 | Cyp2u1 | Cyp2u1 |
| CYP3A | CYP3A4, 3A5, 3A7, 3A43 | Cyp3a11, 3a13, 3a16, 3a25, 3a41, 3a44, 3a57, 3a59 | Cyp3a1, 3a2, 3a9, 3a18, 3a23, 3a62, 3a73 |