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High‐grade B‐cell lymphoma with MYC and BCL6 rearrangements. Diffuse proliferation of medium‐sized lymphocytes with blastoid morphology and a starry‐sky pattern on H&E (A, ×400). The cells were negative for CD10 (B, ×200) and BCL2 (C, ×200). MYC (D, ×200) was positive in >95% of the neoplastic cells. FISH studies with break apart probes highlighted both BCL6 (E) and MYC rearrangements (F).
