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AJNR: American Journal of Neuroradiology logoLink to AJNR: American Journal of Neuroradiology
. 2023 Jan;44(1):E1. doi: 10.3174/ajnr.A7715

Erratum

PMCID: PMC9835905  PMID: 36423950

This is a correction to Yogananda CG, Shah BR, Nalawade SS, et al. MRI-based deep-learning method for determining glioma MGMT promoter methylation status. AJNR Am J Neuroradiol 2021;42:845–52 [10.3174/ajnr.A7029] [33664111]

There was an error in the Python code for the 3-fold cross-validation procedure. This resulted in the use of the training cases instead of the set-aside test cases for the testing procedure for molecular marker accuracy. This caused our reported accuracies from the TCIA/TCGA data set to be artificially inflated. The corrected accuracies for the Table (computed using nnU-Net1), along with the updated receiver operating characteristic (ROC) curve for Fig 3 are provided here. The updated accuracies do not outperform other reported methods for MGMT molecular marker prediction using MR imaging.

Cross-validation results

Fold Description MGMT-Net
% Accuracy AUC Dice Score
Fold no.
 Fold 1 59.75 0.4966 0.7906
 Fold 2 73.49 0.6588 0.7725
 Fold 3 64.63 0.5854 0.7874
Average 65.95 (SD, 0.06) 0.5802 (SD, 0.081) 0.7835 (SD, 0.009)

FIG 3.

FIG 3.

ROC analysis for MGMT-net. Separate curves are plotted for each cross-validation fold along with corresponding area under the curve (AUC) values.

Reference

  • 1.Isensee F, Jaeger PF, Kohl SAA, et al. nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation. Nat Methods 2021;18:203–11 10.1038/s41592-020-01008-z [DOI] [PubMed] [Google Scholar]

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