Figure 5: Common transcription factors explained hormonal changes in expression levels after siOGT in BeWo cells.
(A) TRRUST analysis highlighted the transcription factor responsible for regulating hormones-related genes deregulated in siOGT. Blue Square represents the O-GlcNAcylation status assessed with the O-GlcNAcylated database. (B) RNA-sequencing expression of transcription factors identified by the TRRUST database. TPMs are represented for biological replicate (n=3/group), and significance was analyzed by regular T-Test. *** p < 0.001. (C) Tissue expression for each transcription factor was assessed in BioGPS and normalized by transcription factors.