REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
anti-cytokeratin 18 antibody	Abcam	Cat#ab668
anti-SV40 large T antibody	Abcam	Cat#ab234426; RRID:AB_2928058
goat anti-mouse IgG-647	Biotium	Cat#20281
goat anti-rabbit IgG-555	Biotium	Cat#20033; RRID:AB_10559671
SARS/SARS-CoV-2 Nucleocapsid Monoclonal Antibody	Invitrogen	Cat#MA1-7404; RRID:AB_1018422
normal mouse IgG	Santa Cruz	Cat#sc-2025; RRID:AB_737182
NP-mAb-40	Monoclonal Antibodies against Nucleocapsid Protein of SARS-CoV-2 Variants for Detection of COVID-19	N/A
NP-mAb-56	Monoclonal Antibodies against Nucleocapsid Protein of SARS-CoV-2 Variants for Detection of COVID-19	N/A
p38 MAPK Antibody	Cell Signaling Technology	Cat#9212; RRID:AB_330713
β-Actin Antibody	Cell Signaling Technology	Cat#4967; RRID:AB_330288
Phospho-p38 MAPK (Thr180/Tyr182) Antibody	Cell Signaling Technology	Cat#9211; RRID:AB_331641
Anti-rabbit IgG, HRP-linked Antibody	Cell Signaling Technology	Cat#7074; RRID:AB_2099233
Anti-Na+/K+ ATPase monoclonal antibody	Abcam	Cat#ab76020; RRID:AB_1310695
goat anti-rabbit-Alexa 568 antibody	Biotium	Cat#20102; RRID:AB_10854240
Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ Plus 488	Invitrogen	Cat#A32723; RRID:AB_2633275
anti-His-APC antibody	BioLegend	Cat#362605; RRID:AB_2715818
anti-His antibody	Sigma-Aldrich	Cat#H1029; RRID:AB_260015
Chemicals, peptides, and recombinant proteins
SARS-CoV-2 (2019-nCoV) Nucleocapsid-His Recombinant Protein, Biotinylated	SinoBiological	Cat#40588-V07E
SARS-CoV-2 B.1.1.529 (Omicron) Nucleocapsid Protein (His Tag)	SinoBiological	Cat#40588-V07E34
SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag	Acro	Cat#NUN-C5227
SARS-CoV-2 Nucleocapsid protein, His Tag (B.1.1.529/Omicron)	Acro	Cat#NUN-C52Ht
Lipofectamine 3000 Reagent	Thermo Fisher Scientific	Cat#L3000-015
puromycin	Thermo Fisher Scientific	Cat#A1113803
protein G magnetic beads	GE Healthcare	Cat#28951379
cOmplete™, EDTA-free Protease Inhibitor Cocktail	Roche	Cat#4693132001
PhosSTOP™	Roche	Cat#4906837001
DTSSP	Thermo Fisher Scientific	Cat#21578
sequencing-grade modified trypsin	Promega	Cat#V511A
interleukin-28 alpha	BioLegend	Cat#754202
RANTES	BioLegend	Cat#580202
IP-10	BioLegend	Cat#573502
interleukin-29	BioLegend	Cat#711204
sodium DL-lactate	Sigma-Aldrich	Cat#L4263
L-glutamine	Gibco	Cat#25030-081
pyruvic acid	Sigma-Aldrich	Cat#107360
BD Cytofix/Cytoperm™ Plus	BD Biosciences	Cat#555028
Triton X-100	Sigma-Aldrich	Cat#T8787-100ML
DAPI	Invitrogen	Cat#D1306
Crotonase(crt)	This paper	N/A
Crotonyl-CoA carboxylase/reductase(ccr)	This paper	N/A
2-Mercaptoehtanol	Bio-Rad Laboratories	Cat#1610710
Mini-Proten TGX	Bio-Rad Laboratories	Cat#4561086
BD Cytofix/Cytoperm™ Plus	Merck Millipore	Cat#IEVH85R
hydroxychloroquine(HCQ)	Sigma-Aldrich	Cat#SI-H0915
Dynasore	Sigma-Aldrich	Cat#D7693
SB203580	Selleckchem	Cat#S1076
Critical commercial assays
EZ-PCR kit	Biological Industries	Cat#20-700-20
LEGENDplex™ Human Anti-Virus Response Panel (13-plex) with V-bottom Plate	BioLegend	Cat#740390
LEGENDplex™ HU Proinflam. Chemokine Panel 1 (13-plex) w/FP	BioLegend	Cat#740984
Human RANTES Flex set	BD Biosciences	Cat#558324
Human Soluble Protein Master Buffer Kit	BD Biosciences	Cat#558264
QIAamp® DNA mini kit	QIAGEN	Cat#ID: 56304
RNeasy Mini Kit	QIAGEN	Cat#74106
PowerUp™ SYBR™ Green Master Mix	Applied Biosystems™	Cat#A25741
ibson Assembly® Master Mix – Assembly	NEB	Cat#E2611L
Experimental models: Cell lines
Human embryonic kidney 293T	American Type Culture Collection	Cat#CRL-3216
human cervical cancer HeLa	American Type Culture Collection	Cat#CCL-2
mouse lung cancer LL2	American Type Culture Collection	Cat#CRL-1642
human lung adenocarcinoma A549	American Type Culture Collection	Cat#CCL-185
human colon adenocarcinoma HCT-8	American Type Culture Collection	Cat#CCL-244
mouse mammary gland epithelium 4T1	American Type Culture Collection	Cat#CRL-2539
Human pulmonary alveolar epithelial cells(HPAEpiC)	ScieCellTM	Cat#3200
Oligonucleotides
siRNA-FAM; 5'-CCAACTGAAACGATTTGTGCACCA CTCACTGTCTTTTTTGATGGTAGAGT-3′	MDBio	Cat#NO.5860029552
JUN siRNA; 5′-GAGCGGACCUUAUGGCUAC-3′; 5′-GAACAGGUGGCACAGCUUA-3′; 5′-GAAACGAC CUUCUAUGACG-3′ and 5′- UGAAAGCUCAGAACU CGGA-3′	Dharmacon	Cat#L-003268-00-0005
siIFNAR1; 5′- GCGAAAGUCUUCUUGAGAU-3′; 5′- UGAAACCACUGACUGUAUA-3′; 5′- GAAAAUU GGUGUCUAUAGU-3′ and 5′- GAAGAUAAGGCAA UAGUGA-3′	Dharmacon	Cat#L-020209-00-0005
STEAP2 forward primers for qRT-PCR; 5'- CCTCTG CTTACCGATGAGAAGG-3′	This paper	N/A
STEAP2 reverse primers for qRT-PCR; 5'- CAGGAGGGAAAGTAAGCCAAGG -3′	This paper	N/A
PS RNA#1: Covid-19 viral RNA sequence; 5′-CCAA CTGAAACGATTTGTGCACCACTCACTGTCTTTTT TGATGGTAGAGT-3′	MDBio	N/A
PS RNA#12: Covid-19 viral RNA sequence; 5′-ATTT GTGCACCACTCACTGTCTTTTTTGATGGTAGAG TTGATGGTCAAGT-3′	MDBio	N/A
pLKO.1-LacZ shRNA	National C6 RNAi Core Facility	Cat#TRCN0000072224
pLKO.1-STEAP2 shRNA	National C6 RNAi Core Facility	Cat#TRCN0000297801
Recombinant DNA
pmax-GFP	Lonza	Cat#VDC-1040
pcDNA3.1-SARS-CoV2 N-6xHis tag	this paper	N/A
pcDNA3.1-SARS-CoV2 N(R203K, G204R)-6xHis tag	this paper	N/A
pcDNA3.1-SARS-CoV2 N(omicron)-6xHis tag	this paper	N/A
pcDNA3.1-SARS N-6xHis tag	this paper	N/A
pcDNA3.1-MERS N-6xHis tag	this paper	N/A
pcDNA3.1-229E N-6xHis tag	this paper	N/A
pcDNA3.1-NL63 N-6xHis tag	this paper	N/A
pcDNA3.1-HKU1 N-6xHis tag	this paper	N/A
pcDNA3.1-OC43 N-6xHis tag	this paper	N/A
pET15b-SARS-CoV2 N(P13L)-6xHis tag	this paper	N/A
pET15b-SARS-CoV2 N(31-33 deletion)-6xHis tag	this paper	N/A
pET15b-SARS-CoV2 N(R203K, G204R)-6xHis tag	this paper	N/A