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Methods for RNA sequencing and the PRISM multiplexed cell line panel, summary of the HTS screen, PRISM profiling, colony formation assay, RNA sequencing analysis, X-ray structural comparison of the binding modes of BAY-4931 and T0070907, pharmacodynamic analysis of tumors treated with compounds, HPLC traces of in vivo compounds, and NOESY profiles of compounds 8b and 8c (PDF)
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