Table 5.
Cytotoxic activity of compounds 1–10, 12–13.
| IC50 (µM) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cell lines | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 12 | 13 | Epothilone B |
| KB3.1 | 0.064 | 0.33 | 1.7 | 5.8 | 10.6 | - | - | 30.3 | 0.36 | 0.91 | - | - | 6.5×10-5 |
| L929 | 0.19 | 1.5 | 1.3 | 10.8 | >30.4 | - | - | - | 1.06 | 5.6 | - | - | 6.5×10-4 |
| A431 | 0.085 | 0.33 | 14.3 | 11.0 | 12.0 | n.t | n.t | n.t | 0.04 | 0.17 | n.t | n.t | 1.2×10-4 |
| MCF-7 | 0.14 | 3.1 | 7.3 | 19.3 | 7.44 | n.t | n.t | n.t | 0.02 | 0.36 | n.t | n.t | 8.2×10-5 |
| A549 | 0.16 | 0.73 | 3.1 | 10.3 | 19.7 | n.t | n.t | n.t | 0.43 | 1.0 | n.t | n.t | 6.1×10-5 |
| SKOV-3 | 0.073 | 0.33 | 13.6 | 45.9 | 13.9 | n.t | n.t | n.t | 0.15 | 0.65 | n.t | n.t | 2.9×10-4 |
| PC-3 | 0.14 | 0.29 | 4.2 | 9.4 | 7.3 | n.t | n.t | n.t | 1.1 | 9.7 | n.t | n.t | 9.5×10-4 |
n.t: not tested, (-): no activity. Starting concentration for cytotoxicity assay was 37 µg/mL