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. 2023 Jan 4;613(7944):582–587. doi: 10.1038/s41586-022-05560-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Top – Cas12a binary complex (PDB 5NG6, left) and Cas12a2 (right) with AcrVA1 (PDB 6NMD, green). AcrVA1 interacts with the 5′ crRNA seed in Cas12a, which is not present in Cas12a2. There are also significant clashes between AcrVA1 and the REC lobe of Cas12a2. Middle – Cas12a (left) and Cas12a2 (right) binary complex with a monomer of AcrVA4 (PDB 6NMA, orange). There are severe clashes between the Cas12a2 Insertion domain (dark cyan) and AcrVA4. Clashes are shown as magenta lines.