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. 2022 Nov 9;613(7944):558–564. doi: 10.1038/s41586-022-05514-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a-d, Growth was quantified for lineage A (a), lineage B (b), lineage C (c), and unpassaged SARS-CoV-2 (d, denoted as WT-P0) in comparison to SARS-CoV-2 passaged without nirmatrelvir for 30 passages (denoted as WT-P30). Vero E6 cells were infected with 200 TCID₅₀ of the indicated viruses and viral RNA was quantified at the indicated time points. e, The slope during the exponential phase (between 11 and 24 h post-infection) of growth for the indicated viruses.