Sunisa Prasopporn
Sunisa Prasopporn
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
1,2,
Orawan Suppramote
Orawan Suppramote
2
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
3
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand
2,3,
Ben Ponvilawan
Ben Ponvilawan
2
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2,
Chanette Jamyuang
Chanette Jamyuang
2
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2,
Jantappapa Chanthercrob
Jantappapa Chanthercrob
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
1,
Amphun Chaiboonchoe
Amphun Chaiboonchoe
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
1,
Pimkanya More-Krong
Pimkanya More-Krong
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
1,
Kamonchanok Kongsri
Kamonchanok Kongsri
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
1,
Monthira Suntiparpluacha
Monthira Suntiparpluacha
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
1,
Rawisak Chanwat
Rawisak Chanwat
4
HepatoPancreato-Biliary Surgery Unit, Department of Surgical Oncology, National Cancer Institute, Bangkok, Thailand
4,
Krittiya Korphaisarn
Krittiya Korphaisarn
5
Division of Medical Oncology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
5,
Seiji Okada
Seiji Okada
6
Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan
6,
Somponnat Sampattavanich
Somponnat Sampattavanich
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
1,2,
Siwanon Jirawatnotai
Siwanon Jirawatnotai
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
1,2,*
1
Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
3
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand
4
HepatoPancreato-Biliary Surgery Unit, Department of Surgical Oncology, National Cancer Institute, Bangkok, Thailand
5
Division of Medical Oncology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
6
Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan
Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland
✉*Correspondence: Siwanon Jirawatnotai, Siwanon.jirwatnotai@mahidol.ac.th
This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology
Received 2022 Dec 15; Accepted 2022 Dec 19; Collection date 2022.
Keywords: SMAC mimetics, LCL161, Gemcitabine plus Cisplatin therapy, multidrug resistance, cholangiocarcinoma, acquired vulnerability
Copyright © 2023 Prasopporn, Suppramote, Ponvilawan, Jamyuang, Chanthercrob, Chaiboonchoe, More-Krong, Kongsri, Suntiparpluacha, Chanwat, Korphaisarn, Okada, Sampattavanich and Jirawatnotai
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