CAR |
chimeric antigen receptor |
EGFR2/HER2 |
human epidermal growth factor receptor 2 |
NK |
Natural Killer |
ICB |
immune checkpoint blockade |
PD-1 |
programmed cell death 1 |
CTLA-4 |
cytotoxic T lymphocyte-associated protein 4 |
Ig |
immunoglobulin |
DNAM-1/CD226 |
DNAX Accessory Molecule-1 |
ITIM |
immunoreceptor tyrosine-based inhibition motif |
TIGIT |
T-cell immunoreceptor with Ig and ITIM domains |
IFN |
interferon |
HCC |
hepatocellular carcinoma |
TNF |
tumor necrosis factor |
TILs |
tumor-infiltrating lymphocytes |
Ab |
antibody |
CML |
chronic myeloid leukemia |
AML |
acute myeloid leukemia |
scFv |
single chain variable fragment |
PBMCs |
peripheral blood mononuclear cells |
KO |
knockout |
gRNA |
guide RNA |
WT |
wild-type |
mAb |
monoclonal antibody |
IC |
intracellular signalling domain |
E:T |
effector:target ratio |
BLI |
bioluminescence |