Table 4.

Studies examining the effect of dietary acrylamide exposure on respiratory system cancer types.

Type of Cancer—Reference	Cases	Mean Dietary Acrylamide Intake	Risk
Oral cavity/pharyngeal cancer
Pelucchi et al. (2006) [63]	749	29.24 μg/day (0.40 µg/kg bw/day)	na
Schouten et al. (2009)	OCC: 101 (M: 61-W:40) OHC: 83 (M: 41-W:22)	OCC-M: 18.8 μg/day (0.25 µg/kg bw/day) OCC-W: 18.8 μg/day (0.28 µg/kg bw/day) OHC-M: 18.3 μg/day (0.23 µg/kg bw/day) OHC-W: 20.7 μg/day (0.32 µg/kg bw/day)	No statistically significant relationship was found between dietary acrylamide exposure and OCC cancer. However, it was stated that acrylamide exposure may increase the risk of OCC cancer in non-smokers. OHC: na
Pelucchi et al. (2015) [72]	933	-	na
Filippini et al. (2022) [95]	-	23 μg/day	na
Throat Cancer
Pelucchi et al. (2006) [63]	527	27.10 μg/day (0.36 µg/kg bw/day)	na
Schouten et al. (2009) [116]	LC: 180 (M: 170-W:10)	LC-M: 23.3 μg/day (0.31 µg/kg bw/day) LC-W: 21.0 μg/day (0.35 µg/kg bw/day)	na
Pelucchi et al. (2015) [72]	707	-	na
Filippini et al. (2022) [95]	-	23 μg/day	na
Lung Cancer
Hogervorst et al. (2009) [117]	M: 1.600 W: 295	-	M: na W: A very strong inverse relationship was found between dietary acrylamide exposure and adenocarcinoma.
Hirvonen et al. (2010) [96]	1.703	21.9–55.7 μg/day	A positive correlation was found between dietary acrylamide exposure and lung cancer.
Pelucchi et al. (2015) [72]	3.598	-	na
Liu et al. (2020) [118]	M: 1187 W: 485	Female: 6.8 μg/day Male: 7.0 μg/day	na
Filippini et al. (2022) [95]	-	23 μg/day	na
Respiratory System Cancers
Liu et al. (2017) [104]	104	14.6 ± 8.2 μg/day	The increase in the number of respiratory system cancer cases with dietary acrylamide exposure was found to be statistically significant.

na: No association; OCC: Oral cavity carnicoma; OHC: Oropharynx-hypopharynx cancer; LC: Larynx cancer; M: Man; W: Woman.