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. 2023 Jan 9;28(2):652. doi: 10.3390/molecules28020652

Figure 8.

Figure 8

Anticancer mechanism of C3G in human GC MKN-45 cells. C3G induced apoptosis through ROS-mediated MAPK, STAT3, and NF-κB signaling pathways; arrested cells in the G2/M phase through the AKT signaling pathway; and inhibited cell migration through the β-catenin signaling pathway in human GC MKN-45 cells. Dashed arrows indicate possible regulatory relationships, and dashed boxes indicate the proteins that make up the family. The solid arrows show the relationships confirmed in this study, and the solid boxes show the proteins related to the regulation of the cell cycle and cell migration.