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. 2023 Jan 10;15(1):202. doi: 10.3390/v15010202

Figure 2.

Figure 2

Anti-HIV CAR T cells specifically kill HIV-infected cells in vitro: (A) cytotoxicity assay of autologous B cells at E:T 5:1; (B) cytotoxicity assay of HIV-infected autologous CD4+ T cells at E:T 1:1; (C,D) levels of p24 in supernatants following five day co-culture of CAR T cells and HIV-infected CD8-depleted autologous PBMCs at E:T 1:1. (C): CARs are integrated into AAVS1, (D) CARs are integrated into CCR5; (E) AUC of p24 curves in (C,D) (data presented as means ± SEM, *: p ≤ 0.05, **: p ≤ 0.01, ***: p ≤ 0.001).