Table 4.
Antitumor effects of Calystegia silvatica methanol extract on cancer and normal cell lines.
| a IC50 (µg/mL) | |||
|---|---|---|---|
| Cell Lines | Leaves | Stems | Doxorubicin (Positive Control) |
| b CaCo2 | 682 ± 55 *** | 353 ± 19 *** | 70.1 ± 1 |
| c HeLa | 208 ± 13 *** | 114 ± 5 *** | 40 ± 2 |
| d PC3 | 336 ± 57 *** | 137 ± 18 * | 38 ± 2 |
| e MCF7 | 324 ± 17 *** | 172 ± 15 *** | 36 ± 6 |
| f HepG2 | 593 ± 22 *** | 236 ± 17 *** | 44 ± 3 |
| g WI38 | 543 ± 33 *** | 408 ± 4 *** | 51 ± 4 |
a IC50: The half-maximal inhibitory concentration, b colon cancer (Caco2), c cervical cancer (HeLa), d prostate cancer (PC3), e breast cancer (MCF7), f hepatocellular carcinoma (HepG2) and g normal human fetal lung fibroblast (WI38). The findings are shown as mean ± standard deviation. * p = 0.05, ** p = 0.001 and *** p = 0.0001 show significant changes compared to a positive control. The Calystegia silvatica stems and leaves extracts and doxorubicin were compared using one-way analysis of variance (ANOVA), then Dunnett’s multiple comparisons test.