Table 2.
Binding energies and interacting amino acid residues of recombinant clade A/E and clade B HIV-1 gp120.
| Recombinant Clade A/E | Clade B | |||
|---|---|---|---|---|
| Compound | Binding Energy (kcal/mol) | Amino Acid Residues | Binding Energy (kcal/mol) | Amino Acid Residues |
| NP-008297 | −10.3 | Glu370, Gln258, Pro470, Ile371, Pro363, Ser365, Gln362, Gly471, Thr455, Gly472, and Asn425. | −7.9 | Asp368, Ser365, Ser364, Gly366, Asn425, and Met426. |
| NP-000088 | −9.7 | Glu370, His375, Gln258, Gly472, Gln363, and Ser365 | −7.1 | Gly473, Thr283, Ser364, and Ser365. |
| NP-007382 | −9.6 | Pro470, Gly366, Ile371, Gly473, and Ile475. | −7.2 | Asp457, Arg469, Ser364, Ser365, and Gly472. |
| NP-005003 | −9.3 | Asp457, Asn280, Pro470, and Arg469. | −7.3 | Thr283 and Ala281. |
| NP-007422 | −9.3 | Gln258, Ile371, Thr257, Met373, Glu370, Asn425, Asp280, and Asp457. | −6.7 | Asp474, Arg476, Trp427, Gly473, Asn425, Asp368, and Glu370. |
| NP-001800 | −9.2 | Glu370, Trp427, Gly429, Gln105, and Asn474. | −7.8 | Ser365 and Gln363. |
| NP-005114 | −9.1 | Gln258, Ile371, Gln362, Pro363, Gly471, Asp457, Asn280, and Gly472. | −8.2 | Arg476, Gly472, Pro470, Gly366, Ser364, Glu370, Asn425, Trp427, and Met426. |
| NP-004255 | −9 | Trp427, Gly429, Ile371, Gln258, Pro470, and Gly472. | −7.3 | Arg476, Asp474, Thr455, and Pro470. |
| FRG-00075 | −7.4 | Glu370, Ile371, Ser365, Arg469, and Gly472. | −6.8 | Gly431 and Ser375. |