Table 6.
Adsorption, distribution, metabolism, and excretion properties of the 9 selected compounds.
| Compound Name | TPSA * | Lipophilicity | Water Solubility | GI Absorption ¥ | BBB Permeant £ | Pgp Substrate § | CYP Inhibitor ȡ |
|---|---|---|---|---|---|---|---|
| NP-008297 | 275.5 | 1.79 | Soluble | Low | No | Yes | No |
| NP-004255 | 310.66 | −0.87 | Soluble | Low | No | Yes | No |
| NP-000088 | 234.29 | −0.43 | Soluble | Low | No | Yes | No |
| NP-007422 | 245.29 | 0.07 | Soluble | Low | No | Yes | No |
| NP-005114 | 310.66 | −3.12 | Soluble | Low | No | No | No |
| NP-007382 | 186.12 | 1.91 | Soluble | Low | No | Yes | No |
| NP-005003 | 251.16 | −0.98 | Soluble | Low | No | Yes | No |
| NP-001800 | 251.16 | 0.61 | Insoluble | Low | No | Yes | No |
| FRG-00075 | 71.18 | 1.3 | Soluble | High | No | Yes | No |
* Topological polar surface area. § P-glycoprotein substrate. ¥ gut absorption. £ cross the blood–brain barrier. ȡ CYP450 conversion.