Correction for: Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of Lmna mutant mice

This article has been corrected: The authors found that Western blot images of p-ERK1/2 and ERK1/2 in Figure 4F were from different experiment with protein extracts from Lmna^Dhe/+mice. They replaced the incorrect images with the images of p-ERK1/2 and ERK1/2 in MSC protein extracts from normal and Lamin A/C knockdown (KD) mice. In Figure 4H, the authors corrected a typo where “p-ERK1/2” was mislabeled “p-REK1/2”. The authors also revised the Figure legend for Figure 4F and 4G as follows: “(F) Lamin A/C was knocked down in mouse MSCs using siRNA. (G) Primary MSCs with Lmna^Dhe/+ mutation were isolated from Lmna^Dhe/+ mice.” These corrections have no impact on the experimental outcome or conclusions.

Corrected Figure 4 legend and panels 4F and 4G presented below.

Figure 4.

Increases of osteogenesis and ERK1/2 activation in GD1a-treated Lmna dysfunction MSCs. … dysfunction MSCs. (F) Lamin A/C was knocked down in mouse MSCs using siRNA. (G) Primary MSCs with Lmna^Dhe/+ mutation were isolated from Lmna^Dhe/+ mice. (H) Phosphorylation of ERK1/2 in Lmna dysfunction MSCs treated with GD1a. (I)…. Phosphorylation of ERK1/2 was determined by western blotting with anti-p-ERK1/2. ERK1/2 was used as a loading control. Values represent mean ± SD; ^&&&p < 0.001 indicates a significant difference from the normal MSCs; ***p < 0.001 indicates a significant difference from the Lmna^Dhe/+ mutant MSCs; ^###p < 0.001 indicates a significant difference from the Lamin A/C KD MSCs. ^$$$p < 0.001 indicates a significant difference from the U0126-treated MSCs.