Skip to main content
[Preprint]. 2023 Jan 8:2023.01.08.523162. [Version 1] doi: 10.1101/2023.01.08.523162

Figure 1: PASTE2 partial alignment of overlapping slices.

Figure 1:

Four thin slices (red, green, blue, purple) are dissected from the same tissue and placed on an ST array. However, these slices only partially overlap in the z-coordinate direction. The inputs to PASTE2 are the four ST slices, including gene expression, spot locations, and optionally, histology images. PASTE2 computes a partial alignment of each pair of adjacent slices by selecting subsets of spots from each slice that preserve transcriptional, spatial and image similarity. PASTE2 uses the partial alignment to create a 3D spatial reconstruction of the tissue.