Figure 3. RBM12 independently impacts the cAMP and transcriptional signaling steps.
(A) PCK1 mRNA expression in untreated cells or in cells treated with either 1 μM isoproterenol (wild-type cells) or 10 nM isoproterenol (RBM12 knockout cells) for 1 hour (n = 3). (B) PCK1 mRNA expression in untreated cells or in cells treated with 150 μM 8-CPT-cAMP for 1 hour (n = 4). All data are mean ± SEM. Statistical significance was determined using two-way ANOVA with Tukey’s correction (A-B). See also Figure S3.