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. 2023 Jan 30;41(9):1550–1553. doi: 10.1016/j.vaccine.2023.01.064

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Fig. 1 — Specific T cell responses in patients after vaccination. S-specific CD4 T cell and CD8 T cell responses (total cytokines: IFN-γ +/- IL-2+/- TNFα) of patients after the second (Vaccine 2) and third (Vaccine 3) vaccine injection (n = 14) after overnight SARS-CoV-2-specific stimulation (S peptide pools) in vitro as compared to unstimulated condition (A). Individual S-specific CD4 and CD8 T cell responses after the second (Vaccine 2) and third (Vaccine 3) vaccine injection (n = 14). Results are represented background subtracted (B). Median values ± IQR are shown, and Wilcoxon test was used for comparisons. Functional composition of SARS-CoV2-specific CD4⁺ and CD8⁺ T cell responses in vaccinated patients after the second (Vaccine 2) and third (Vaccine 3) vaccine injection. Responses are color coded according to the combinations of cytokines produced. The arcs identify cytokine-producing subsets (IFN-γ, IL-2, and TNF-α) within the CD4 + and CD8 + T cell populations (C).