In the original publication [1], there were mistakes in the representative images for the PBS and FGF controls and FGF + Difluoroallicin (Figure 5). Specifically, in Figure 5, there were unintentional mistakes in incorporating representative CAM images from other archived files. Additionally, the error in the FGF + Difluoroallicin panel was due to inadvertent exchange with a panel from another contemporaneous study. The correct image for those three panels (PBS, FGF and FGF + Difluoroallicin) appears in the corrected figure. The authors apologize for these unintentional mistakes. However, the mean % inhibition of FGF-mediated angiogenesis by difluoroallicin (>60% inhibition) was unaffected, as shown in Figure 3. These changes in the representative images do not affect the conclusions regarding the biological activity of the compounds studied.
Figure 5.
Representative images of CAM neovascularization induced by FGF (bFGF) and its inhibition by the various garlic-derived compounds, including ajoene (8), allicin (1) and difluoroallicin (12) each at 4 µg/20 µL/CAM. The images shown are representative single images selected for illustration of the general anti-angiogenesis efficacy of the organosulfur compounds and not for quantitative purposes.
Figure 5 (Corrected):
This correction was approved by the Academic Editor. The original publication has also been updated.
Footnotes
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Reference
- 1.Block E., Bechand B., Gundala S., Vattekkatte A., Wang K., Mousa S.S., Godugu K., Yalcin M., Mousa S.A. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules. 2017;22:2081. doi: 10.3390/molecules22122081. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]