Table 1.
Characteristics of included reviews (n=26)
| Reference | Condition | Antidepressant class | Prospective registration | Type of review | No of trials (No of participants) with data for pain | No (%) of trials with industry ties* |
|---|---|---|---|---|---|---|
| Wang 202216 | Postoperative pain | SNRI, SSRI | Yes | Non-Cochrane | 17 (1242) | 0 |
| Roberts 202252 | Aromatase inhibitor therapy induced pain in breast cancer | SNRI | Yes | Cochrane | 1 (255) | 0 |
| Ferreira 202132 | Back pain, sciatica, knee osteoarthritis | SNRI, SSRI, TCA, NDRI, SARI, tetracyclic/atypical | Yes | Non-Cochrane | 30 (4445) | 14 (47) |
| Farag 202153 | Burning mouth syndrome | SARI | No | Non-Cochrane | 1 (37) | 1 (100) |
| Ford 202136 | Functional dyspepsia | SSRI, TCA, tetracyclic/atypical | No | Non-Cochrane | 5 (618) | 0 |
| Do 202154 | Atypical chronic orofacial pain | SNRI, TCA | Yes | Non-Cochrane | 2 (60) | 1 (100) |
| Imamura 202055 | Bladder pain syndrome | TCA | Yes | Cochrane | 2 (279) | 0 |
| Ford 201956 | Irritable bowel syndrome | SSRI, TCA | Yes | Non-Cochrane | 7 (351) | 1 (14) |
| Caruso 201935 | Neuropathic pain | SNRI | Yes | Non-Cochrane | 12 (3010) | 9 (75) |
| Perez-Lopez 201957 | Vulvodynia | TCA | No | Non-Cochrane | 1 (58) | 0 |
| Christophorou 201958 | Acute oral mucositis | TCA | No | Non-Cochrane | 1 (140) | 0 |
| Franco 201959 | Chronic prostatitis | SSRI | Yes | Cochrane | 1 (42) | 1 (100) |
| Welsch 201845 | Fibromyalgia | SNRI | Yes | Cochrane | 15 (6918) | 14 (93) |
| Welsch 201846 | Fibromyalgia | Tetracyclic/atypical | Yes | Cochrane | 3 (591) | 2 (66) |
| Jackson 201751 | Chronic tension-type headache | TCA, tetracyclic/atypical | No | Non-Cochrane | 4 (197) | 0 |
| Gebhardt 201631 | Depression and comorbid chronic pain | SNRI, SSRI | No | Non-Cochrane | 14 (4380) | 15 (79) |
| Alviar 201660 | Phantom limb pain | TCA | Yes | Cochrane | 1 (39) | 0 |
| Walitt 201547 | Fibromyalgia | SSRI | Yes | Cochrane | 6 (343) | 5 (83) |
| Moore 201549 | Fibromyalgia | TCA | Yes | Cochrane | 4 (275) | 1 (25) |
| Banzi 201561 | Chronic migraine | SSRI | Yes | Cochrane | 2 (82) | 1 (20) |
| Banzi 201550 | Chronic tension-type headache | SNRI, SSRI | Yes | Cochrane | 2 (127) | 1 (50) |
| Finnerup 201517 | Neuropathic pain | TCA | No | Non-Cochrane | 14 (948) | 0 |
| Atluri 201562 | Non-cardiac chest pain | SSRI | No | Non-Cochrane | 4 (184) | 2 (50) |
| Cheong 201463 | Chronic pelvic pain | SSRI | Yes | Cochrane | 1 (23) | 0 |
| Richards 201164 | Rheumatoid arthritis | TCA | Yes | Cochrane | 7 (482) | 1 (17) |
| Tort 201248 | Fibromyalgia | MAOI | Yes | Cochrane | 2 (121) | 1 (50) |
SNRI=serotonin-norepinephrine reuptake inhibitors; SSRI=selective serotonin reuptake inhibitors; TCA=tricyclic antidepressants; NDRI=noradrenaline-dopamine reuptake inhibitors; SARI=serotonin antagonist and reuptake inhibitors; MAOI=monoamine oxidase inhibitors.
*
Pain data (primary outcome).