Table 3.

Physiologic and ICU resuscitation data by MHI

	MHI ≤ 0.4 t0	MHI > 0.4 t0	MHI ≤ 0.4 t6	MHI > 0.4 t6
Clinical and macrocirculatory data
Temperature, °C	36.1 ± 0.7	36.3 ± 0.8	37.5 ± 0.7	37.3 ± 0.8
Heart rate, bpm	82 ± 17	85 ± 9	87 ± 14	89 ± 13
Mean arterial pressure, mm Hg	77 ± 9	74 ± 11	77 ± 12	76 ± 10
Central venous pressure, mm Hg	9 ± 4	11 ± 4	7 ± 4	7 ± 5
Cardiac index, L/min·m2	2.4 ± 0.8	2.2 ± 0.5	2.6 ± 0.6	2.7 ± 0.7
SVRi, dyn·s·cm−5·m2	2,473 ± 988	2,422 ± 708	2,189 ± 561	2,169 ± 495
Laboratory data
Hemoglobin, g/dL	12.1 ± 1.6	13.1 ± 1.5*	11.9 ± 1.3	12.4 ± 1.9
Hematocrit, %	37 [34–39]	41 [36–43]*	37 [31–39]	38 [35–41]
pH	7.31 [7.29–7.37]	7.31 [7.27–7.33]	7.35 [7.31–7.4]	7.36 [7.31–7.39]
PaO2, mm Hg	149 [94–250]	176 [113–269]	109 [86–116]	105 [86–142]
PCO2, mm Hg	41 [36–45]	43 [40–47]	41 [37–45]	36 [33–41] †
Mixed venous O2 saturation, %	72 [67–76]	73 [62–80]	67 [63–71]	65 [60–72]
Glucose, g/dL	154 ± 33	163 ± 30	150 ± 34	157 ± 32
Volume resuscitation (first 6 h)
Intravenous crystalloid, L	—	—	1.4 ± 0.9	1.7 ± 0.8
RBC transfusion, n patients; units	—	—	3; 1 [1–2]	3; 3 [2–3]
FFP transfusion, n patients; units	—	—	3; 2 [2–2]	3; 2 [1–4]
Platelet transfusion, n patients; units	—	—	2; 2 [2–2]	1; 2 [2–2]
Urine output, mL	—	—	610 ± 360	600 ± 240
Blood loss, mL	—	—	170 [110–300]	290 [160–370]
6-h volume balance	—	—	(+) 690 ± 870	(+) 1,050 ± 820
Vasopressor support
Phenylephrine, n patients (%) mcg/kg/min	10 (33) 0.6 [0.4–1.0]	3 (15) 0.5 [0.3–0.6]	11 (37) 0.8 [0.5–1.0]	7 (35) 0.8 [0.5–1.1]
Inotropic support
Epinephrine, n patients (%) mcg/kg/min	24 (80) 0.04 [0.02–0.07]	14 (70) 0.03 [0.02–0.05]	21 (70) 0.02 [0.01–0.04]	14 (70) 0.04 [0.02–0.06]

Data presented as mean ± standard deviation, median [quartile range], and frequency (%).

^*P < 0.05.

^†P < 0.01.

MHI indicates microcirculatory heterogeneity index; T0, ICU admission; T6, 6 hours after ICU admission.