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. 2022 Dec 5;614(7946):136–143. doi: 10.1038/s41586-022-05605-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a-d) RNA-seq analyses of CD11c⁺ MHCII^hi cells in the dLN 24h after B16-F10-OVA cell engraftment in control mice (n = 5 mice) or Clec9acre:Bmal1^flox mice (n = 3 mice), from 2 independent experiments. (a) Expression (Counts per million (CPM)) of Per1 and Dbp in CD11c⁺ MHCII^hi cells from control mice, Cosinor analysis. (b) Principal Component (PC) analyses of each sample from sequencing of CD11c⁺ MHCII^hi DCs in control mice. (c) Significantly enriched pathways from PC1 in control cells with CD28 signalling pathways highlighted in red, shown for control and Clec9acre:Bmal1^flox CD11c⁺ MHCII^hi cells. The vertical dashed line represents the significant p values, hypergeometric test. (d) GO Biological Process interactions in the PC2 gene cluster for control cells. All data are represented as mean ± SEM.

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