Fig. 4.

Differentially expressed novel lncRNAs. Heatmaps representing the novel lncRNAs differentially expressed between failing (11 ICM, 10 DCM) and control (5) hearts. A. control vs. ICM, B. control vs. DCM group. A false discovery rate (FDR) < 0.05 and a fold change ≥2 are used as cut-offs for differential expression. Centered gene expression values corresponding to the subtraction of the row-wise median value of all lncRNAs from the expression value of each lncRNA are represented as a color scale. The red color indicates an up-regulation and the green color a down-regulation in failing vs non-failing hearts. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)