Figure 5:

The percentile rank of cognate ligands (Y-axis) as a function of overlap between the alternative interface and the original interface. Solid black circles are reliable and hollow circles are unreliable predictions. (A) The average percentile rank of cognate ligands as we deviate away from the original interface of CTLA4:CD80, and (B) in CTLA4:CD86 interface. Each ProtLID result is assessed for reliability: solid circles are reliable and hollow circles are unreliable. Blue circles show the average results for a given interface size for all interfaces, while pink circles show the average of only the reliable predictions. The corresponding standard error of the mean around the averages of all points and only reliable points are shown by vertical blue and pink lines, respectively. The solid orange line shows the random expectation, with the corresponding standard error of the mean shown by the orange dashed lines.